The red Holden Commodore sedan collided with a silver Mazda hatch on Barwarre Road in Marshall, in the city’s south, about 6.15pm yesterday.
Police said the Mazda driver was airlifted to hospital with life-threatening injuries but they were told the male Commodore driver “dumped the vehicle and fled on foot”.
His two passengers, a man and a woman, remained behind and were both taken to hospital with minor injuries.
Police are still investigating exactly what happened in what they termed a “hit-run collision”.