Police were called to a single-vehicle crash in Goodna, Ipswich at 8.30pm after a Toyota Landcruiser struck a tree on a median island of Whitmore Crescent.
The car rolled a number of times.
The driver and passenger, both 17-year-old boys, were taken to Princess Alexandra Hospital, where they remain in a critical condition.
Three other passengers, aged 16 and 17, received minor injuries.
Investigations are ongoing.
