Emergency services were called to the Princes Highway at Kiah, 15 kilometres south of Eden, where two vehicles collided at 1.45pm today.
Two people who were inside one of the vehicles died at the scene, while two other people who were in the other car suffered serious injuries.
A man in his 60s suffered chest injuries, while a woman in her 70s was flown to Canberra Hospital with chest, abdominal and pelvic injuries.
It is the second fatal crash in the Eden area this week.
