The home of Ellouisa Brighton Gibson, 36, (pictured) and partner Justin Gibson, 34, in Harristown, 130km west of Brisbane, erupted up in flames just after midnight on Wednesday

Two more children have died from their injuries after a suspicious blaze ripped through a house in Queensland, putting the death toll at three. 

Six people managed to escape as the home on Merritt Street in Harristown, Toowoomba, went up in flames at about 12.30am on Wednesday.

The body of a nine-year-old boy was found inside while Ellouisa Brighton Gibson, 36, Justin Gibson, 34, and several children were rushed to hospital.

Queensland Police announced on Thursday that two girls, aged four and seven, died at Queensland Children’s Hospital overnight after succumbing to their injuries. 

An investigation has been launched into the cause of the blaze with police treating it as suspicious. 

The home was designated as a remained a crime scene on Wednesday, with  homicide detectives called in. 

‘Police are treating a house fire as suspicious,’ a Queensland Police spokesman said.

‘At this time, police are not looking for anyone else in connection to this incident.’ 

The home of Ellouisa Brighton Gibson, 36, (pictured) and partner Justin Gibson, 34, in Harristown, 130km west of Brisbane, erupted up in flames just after midnight on Wednesday

The home of Ellouisa Brighton Gibson, 36, (pictured) and partner Justin Gibson, 34, in Harristown, 130km west of Brisbane, erupted up in flames just after midnight on Wednesday

Three of the couple's five children (pictured) have now been killed by the blaze

Three of the couple’s five children (pictured) have now been killed by the blaze

Two more children have died following a suspicious house fire in Toowoomba

Two more children have died following a suspicious house fire in Toowoomba

The 36-year-old woman remains in a critical condition at the Royal Brisbane and Women’s Hospital under police guard. 

The 34-year-old was in a stable condition with serious injuries while an 18-year-old male is believed to have a hand injury.

They were discharged on Thursday morning. 

An 11-year-old boy was uninjured, police said. 

‘This is a tragic event and we are deeply saddened by this incident,’ Detective Inspector Renee Garske said.

She confirmed investigations would include whether domestic violence played a role in the fire.

When asked if the seven people involved were related, Insp Garske said: ‘We are working through that information to determine the status of the relationships at that home address.’

Neighbours smashed windows in an attempt to free the children from the home.

Overnight, a four-year-old girl and seven-year-old girl died at Queensland Children's Hospital

Overnight, a four-year-old girl and seven-year-old girl died at Queensland Children’s Hospital

Mother-of-five Ellouisa Brighton Gibson (pictured) has been put under police guard as she fights for life in hospital in a serious condition

Mother-of-five Ellouisa Brighton Gibson (pictured) has been put under police guard as she fights for life in hospital in a serious condition

Neighbour Will Cuffe ran to help the family as soon as he saw the fire.

‘We were awake and heard some loud shouting, so we went to see what was happening and saw a lot of people out on the street,’ he told The Courier Mail.

‘We heard the smoke alarms, then saw the smoke and flames. After we saw the smoke, it took about three minutes and the house just went up in flames

‘We saw the mother, the father and some of the young kids, The mother was holding the kids and taking them to the ambulance. 

‘Two of the young kids were walking, but they were really badly burnt.’ he said. ‘The dad had a cut on his arm.’

A witness who phoned Triple-0 said the home was fully engulfed by the time he ended the call to emergency services.

Queensland Fire and Rescue Service station manager Neil Goodman said fire crews located the nine-year-old’s body near the front door.

‘Once (crews) could bring the fire under control sufficiently, just near the front door, they located one (deceased person),’ Mr Goodman told 7News.

Queensland Police confirmed it is treating the fire as suspicious

Queensland Police confirmed it is treating the fire as suspicious

Homicide detectives were called to assist in Queensland Police's investigation on Wednesday

Homicide detectives were called to assist in Queensland Police’s investigation on Wednesday

A woman who escaped the fire remains in a critical condition under police guard

A woman who escaped the fire remains in a critical condition under police guard

The family’s dog survived the fire and was being cared for by a neighbour. 

Mr Goodman said firefighters were greeted with a ‘wall of flame and heavy smoke’ when they arrived at the scene as the fire mostly impacted the front of the home.

‘The guys had quite a difficult time making access and getting in to conduct a primary search,’ Mr Goodman said.

After speaking with a family member who was ‘hysterical’, Mr Goodman advised fire and rescue crews on where they might be able to find the missing child. 

‘We’re all fathers, we’ve all got children, so its always hard, it’s a little bit harder when its sort of similar to your own situation,’ Mr Goodman said.

It took about 30 minutes for four fire crews to extinguish the fire.

Anyone with information or relevant vision, including CCTV or dashcam footage, is urged to contact police or Crime Stoppers on 1800 333 000. 

1800 RESPECT (1800 737 732) 

Lifeline 13 11 14

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