Three people have been rushed to hospital with life-threatening injuries after a car and truck collided head-on in South Australia.

Emergency services were called to the crash Riddoch Highway just south of Naracoorte about 9.30am.

The driver of the truck suffered minor injuries and was taken to hospital.

Police said the three occupants of the car were rushed to hospital.

The Riddoch Highway has been closed between Edenhope and Wrattonbully Roads.

Major crash investigators were dispatched to the scene.

Road diversions have been put in place, and the road is expected to be closed for several hours.

Drivers have been asked to avoid the area.

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