The Aga Khan, who became the spiritual leader of the world’s millions of Ismaili Muslims at age 20 as a Harvard undergraduate and poured a material empire built on billions of dollars in tithes into building homes, hospitals and schools in developing countries, has died. He was 88.

His Aga Khan Foundation and the Ismaili religious community announced on their websites that His Highness Prince Karim Al-Hussaini, the Aga Khan IV and 49th hereditary imam of the Shia Ismaili Muslims, died Tuesday in Portugal surrounded by his family.

They said an announcement on his successor would come later.

The Aga Khan, center, smiles as he arrives at the Memorial Church on the campus of Harvard University before addressing an audience, Thursday, Nov. 12, 2015, in Cambridge, Mass. The Aga Khan, spiritual leader to millions of Muslims, spoke about the challenges to a pluralistic society. (AP Photo/Steven Senne) (AP)

It said an announcement on his successor would come later.

Considered by his followers to be a direct descendant of the Prophet Muhammad, His Highness Prince Karim Aga Khan IV was a student when his grandfather passed over his playboy father as his successor to lead the diaspora of Shia Ismaili Muslims, saying his followers should be led by a young man “who has been brought up in the midst of the new age.”

Over decades, the Aga Khan evolved into a business magnate and a philanthropist, moving between the spiritual and the worldly and mixing them with ease.

Treated as a head of state, the Aga Khan was given the title of “His Highness” by Queen Elizabeth in July 1957, two weeks after his grandfather the Aga Khan III unexpectedly made him heir to the family’s 1,300-year dynasty as leader of the Ismaili Muslim sect.

He became the Aga Khan IV on Oct. 19, 1957, in Dar es Salaam, Tanzania, on the spot where his grandfather once had his weight equaled in diamonds in gifts from his followers.

He had left Harvard to be at his ailing grandfather’s side, and returned to school 18 months later with an entourage and a deep sense of responsibility.

“I was an undergraduate who knew what his work for the rest of his life was going to be,” he said in a 2012 interview with Vanity Fair magazine. “I don’t think anyone in my situation would have been prepared.”

A defender of Islamic culture and values, he was widely regarded as a builder of bridges between Muslim societies and the West despite — or perhaps because of — his reticence to become involved in politics.

Prime Minister Justin Trudeau, left, meets with the Aga Khan on Parliament Hill in Ottawa on May 17, 2016. Trudeau violated conflict of interest rules when he vacationed last Christmas at the private Bahamian island owned by the Aga Khan, the country’s federal ethics commissioner concluded on Dec. 20, 2017. (Sean Kilpatrick/The Canadian Press via AP, File) (AP)

The Aga Khan Development Network, his main philanthropic organization, dealt mainly with issues of health care, housing, education and rural economic development.

A network of hospitals bearing his name are scattered in countries where health care had lacked for the poorest, including Bangladesh, Tajikistan and Afghanistan, where he spent tens of millions of dollars for development of local economies.

His eye for building and design led him to establish an architecture prize, and programs for Islamic Architecture at MIT and Harvard. He restored ancient Islamic structures throughout the world.

Accounts differ as to the date and place of Prince Karim Aga Khan’s birth.

According to “Who’s Who in France,” he was born on Dec. 13, 1936, in Creux-de-Genthod, near Geneva, Switzerland, the son of Joan Yarde-Buller and Aly Khan.

The extent of the Aga Khan’s financial empire is hard to measure. Some reports estimated his personal wealth to be in the billions.

The Ismailis — a sect originally centered in India but which expanded to large communities in east Africa, Central and South Asia and the Middle East — consider it a duty to tithe up to 10 per cent of their income to him as steward.

“We have no notion of the accumulation of wealth being evil,” he told Vanity Fair in 2012.

“The Islamic ethic is that if God has given you the capacity or good fortune to be a privileged individual in society, you have a moral responsibility to society.”

He is survived by three sons and a daughter.

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