Officers were called to Awaba Street in Mosman at 11pm after reports that a man was stabbed in his thigh.
A 16-year-old boy was found at that home by emergency responders.
He said he had been stabbed by two men who then fled from the scene.
An investigation into the circumstances around the stabbing started.
Officers entered a home on the same street and arrested two men aged 18 and 20, following the incident.
They have been taken to Chatswood for questioning.
