The fire broke out at an address on the Princes Highway in Eumemmerring just before 6am today.
It’s understood the vacant building was formerly a Hog’s Breath Cafe.
Police are treating the fire as suspicious and are investigating.
Any witnesses or anyone with information is urged to contact Crime Stoppers on 1800 333 000.
The Princes Highway was closed in both directions between Olive Road and Doveton Avenue.