Roads have been closed, a bridge has collapsed and major sections of the Bruce Highway have been closed after days of serious rain.
The road closures have made it difficult for suppliers to get their food into stores across the region.
Some shelves were partially empty at Coles in Innisfail yesterday.
Meat and fresh produce sections appeared to have the most serious shortages.
Coles in Cairns was also reportedly hit by shortages of fresh produce, with a glut of bananas remaining on the shelves.
Woolworths in Cairns also appeared to have major supply issues.
Widespread road closures around Cairns have delayed deliveries.
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It is understood that Coles has stocks ready to be delivered as soon as the roads are open.
A spokesperson for the company said Coles was monitoring the situation.
“Our team worked hard to prepare our stores with essential supplies ahead of this weather event, and we are working closely with suppliers, transport partners and local authorities to maintain deliveries where roads remain accessible.”
“We ask customers to only buy what they need so that everyone in the community can access essential items.”
Woolworths has also been contacted for comment.