Eleven-year-old Daniel Huxtable was seen on Lime Street at about 11am on Tuesday.
Police are searching the area with the assistance of PolAir.
Family and police hold serious concerns for his welfare as he lives with autism and is non-verbal.
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Daniel is described as being of Caucasian appearance, medium build and red hair.
He was last seen wearing a Canberra Raiders cap, blue shirt, dark blue shorts, light-up blue sneakers and was carrying a green and blue backpack.
If you see Daniel, call triple-zero (000) immediately.