9A second teenager has been charged over a stabbing at a popular Melbourne nightclub on Sunday.

A 31-year-old Endeavour Hills man was rushed to hospital suffering life-threatening injuries after he was allegedly set upon by two men armed with a knife and a machete at Revolver Upstairs on Chapel Street about 4am on Sunday.

Today a 19-year-old Greenvale man handed himself into police and was arrested and charged with intentionally causing serious injury and possessing a controlled weapon in vicinity of licenced premises.

Bounassif was arrested at a Craigieburn property yesterday. (Nine)

He was also found to be in possession of drugs including MDMA and cannabis and was charged accordingly.

A 31-year-old man suffered life threatening injuries after he was allegedly stabbed at the Chapel Street Venue. (Nine)

Bounassif, who was on bail when he allegedly slashed the club patron, fronted court today where he was remanded to appear again in December.

The accused was supported by his parents as the court heard he suffers from depression, anxiety, ADHD and PTSD.

Terrified patrons who witnessed the attack said staff used tea towels to stop the man bleeding before paramedics arrived to the incident on September 15.

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