A man on an afternoon run has been killed and two drivers are injured after a two-car collision in Melbourne’s south-east.

Police said the crash occurred between about 2.30pm on Belgrave-Hallam Road in Narre Warren North, shortly after a Mazda and a ute both overtook a car and a truck travelling along the main road.

It’s understood the Mazda then returned to the left lane, before the ute veered into its path and lost control, crossing a footpath and striking the man, who was running on the footpath.

A man on an afternoon run has been killed and two drivers are injured after a two-car collision in Melbourne's south-east.
A man on an afternoon run has been killed and two drivers are injured after a two-car collision in Melbourne’s south-east. (Nine)

Police are still working to identify the victim, who is believed to be aged in his 30s.

Detectives said the ute hit a metal railing and became mangled between the railing and a tree, while the Mazda flipped onto its side.

The driver of the ute, aged in his 30s, was taken to Dandenong Hospital under police guard.

The driver of the Mazda, a woman aged in her 40s, was taken to Dandenong Hospital in a stable condition.

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