Flight QF643 departed Sydney en route to the Western Australian capital at around 8.40am, but turned back after only 25 minutes.
The flight landed normally and taxied to the gate without issue after the captain requested a priority landing.
The plane was met by emergency services after it landed, however no injuries have been reported.
It is understood no smoke was seen in the cabin.
A PAN was declared by Air Trafffic Control, which is a standard urgency signal.
“One of our Sydney to Perth flights returned to Sydney shortly after take-off this morning, after reporting a technical issue,” a spokesperson for Qantas confirmed.
“Our pilots are highly trained to handle situations like this and the aircraft landed safely after the appropriate procedures were conducted.
“We understand this would have been an unsettling experience for customers and apologise for the inconvenience.
“Our engineers will be checking the aircraft today and we will be conducting an investigation into what caused the issue.”
Passengers were offered an additional flight and it was scheduled to leave at 11.30am today.