The vaccine consists of mRNA, which primes the patient’s immune system to recognise the mutations on the cancer cells as foreign invaders.
Each vaccine is personalised – using the patient’s own tissue biopsy to sequence the mutations, much like identifying a fingerprint.
A trial involving 150 high-risk patients produced “exciting” results, according to Moderna chief medical officer Paul Burton.
“The combination of a personalised cancer vaccine plus Keytruda reduced the risk of either dying from cancer, or having the cancer progress, by 44 percent,” Burton said.
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Professor Georgina Long of the Melanoma Institute of Australia said it could be the “penicillin moment” in cancer treatment.
The institute will carry out confirmatory studies, while a larger trial is set to take place next year.
It’s even hoped people with other kinds of cancer could benefit.