Just after 6am, police allege the driver of the utility failed to stop for a routine check at on Alfords Point Road, Menai, resulting in a pursuit.
Soon after, the ute crashed into another vehicle before grinding to a halt.
The man was pronounced dead at the scene, while the other driver remained unharmed.
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Motorists have been advised to avoid the area, with Alfords Point Road closed in both directions and diversions in place.
An investigation has commenced into the incident.