A man, 45, and an 11-year-old girl have died in a crash on the NSW mid-north coast, after their car ran off the road and down an embankment.

Two young boys, aged eight and nine, were airlifted to John Hunter hospital where they remain tonight.

It was a concerned relative who raised the alarm about 1am, after the man and three young children never arrived at their destination as planned.

Double fatal crash NSW mid-north coast
A man, 45, and an 11-year-old girl have died in a crash on the NSW mid-north coast, while two boys recover in hospital, after their car ran off the road and down an embankment. (9News)

“The concerns were based around the fact that the persons were believed to be travelling to a relative’s residence and they failed to arrive,” NSW Police Chief Inspector Timothy Bayly said.

Around 3am, officers found the SUV down an embankment off The Bucketts Way, a long winding rural road near Gloucester, around a 3 hour drive North of Sydney.

The 45-year-old driver and an 11-year-old girl died, while the two young boys were trapped in the vehicle.

Double fatal crash NSW mid-north coast
Two young boys, aged eight and nine, were airlifted to John Hunter hospital where they remain tonight. (9News)

After being freed they were rushed to hospital, with the nine-year-old suffering significant fractures to both his legs, while the eight-year-old was physically unscathed. Both were in shock.

Investigators are now appealing for anyone who may have seen the crash to come forward as they try to piece together the tragedy.

So far this year, 269 people have now lost their lives on NSW roads.

You May Also Like

Elizabeth Hurley cozies up to Billy Ray Cyrus on ‘Tennessee weekend’ after debuting romance

Elizabeth Hurley is continuing to flaunt her new romance with Billy Ray…

Jeffrey Epstein victim Virginia Giuffre’s sister-in-law speaks out after her death: ‘The world lost a fierce warrior’

Virginia Giuffre’s sister-in-law, Amanda Roberts, has spoken out following her death, saying…

Bondi Junction attacker had 'preoccupation with death' before rampage, inquest told

Before he murdered six people in a busy metro shopping centre during…

Lakers’ JJ Redick rips officials over no-call on ‘blatant trip’ of Luka Doncic in brutal Game 4 loss

JJ Redick went off on the officials after Sunday’s loss to the…