Patrolling officers came across the crash on the highway near Hart Street at Tempe about 11.25pm yesterday.
Paramedics continued to give the man first aid but he died at the scene.
He is yet to be formally identified.
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The driver of the Toyota Yaris, a 54-year-old man, was taken to the Royal Prince Alfred Hospital in a serious but stable condition.
Anyone with information is urged to contact Crime Stoppers on 1800 333 000.
