Police carried out a surprise search of a property in Henderson, Nevada, yesterday, confirming it was related to the investigation.
Witnesses described the 10pm raid as loud, with police using bullhorns and lights.
Several did so, but there have been no reports of any arrests.
Lieutenant Jason Johansson of the Metropolitan Police told the Review Journal the search was connected to the Shakur case.
“It has been a while,” he said.
“It’s a case that’s gone unsolved and hopefully one day we can change that.”
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Shakur was gunned down while sitting inside a black car with Marion “Suge” Knight, head of Death Row Records.
The two were stopped at a red light near the Las Vegas Strip when a white Cadillac pulled up next to them and gunfire erupted.
Shot multiple times, Shakur was rushed to a hospital, where he died a week later, aged 25.
No arrests have ever been made.
Largely considered one of the most influential and versatile rappers of all time, the six-time Grammy Award nominated Shakur has had five No. 1 albums: 1995’s Me Against the World, 1996’s All Eyez on Me, and three posthumous releases: 1996’s The Don Killuminati: The 7 Day Theory, which was recorded under the name Makaveli, as well as 2001’s Until the End of Time and 2004’s Loyal to the Game.