Spacey began by discussing how he got involved in the theatre, joking that his mother would say he began acting the moment he emerged from the womb.
The testimony provided some light history on his life before delving into the serious matter before the court.
One man who called Spacey a “vile sexual predator” said he passed out or fell asleep at the actor’s London flat and woke up to find the actor performing oral sex on him.
Spacey has denied the charges and is expected to provide a vigorous defense.
The 63-year-old American actor was one of the biggest stars of the stage, and silver and small screens, when sexual misconduct accusations brought his career to a halt.
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If convicted, he could face a prison term that would doom his hopes of a comeback.
Spacey told German magazine Zeit in an article published last month: “There are people right now who are ready to hire me the moment I am cleared of these charges in London.”
Spacey has pleaded not guilty to 12 charges that include sexual and indecent assault counts and one count of causing a person to engage in penetrative sexual activity without consent.
Spacey, who owns homes in London and the US, is free on unconditional bail.