Emergency services were called to the intersection of Harburg Drive and Logan River Road in Beenleigh about 7pm.
Investigators believe the crash occurred when a white Mazda 3, turning right onto Harburg Drive, collided with a Suzuki RN85 motorbike traveling west along Logan River Road.
The motorbike rider, a 29-year-old man from Holmview, was found with critical injuries.
He died at the scene despite efforts to revive him.
The driver of the Mazda, a 26-year-old man from Bethania, was the sole occupant and was unharmed.
