Detectives have launched an investigation after a convicted murderer was stabbed to death in prison while serving a 33-year sentence for the brutal killing of a teenage boy in Sydney.

Aymen Terkmani, 31, was killed at Lithgow Correctional Centre, about 150km west of Sydney, yesterday afternoon, police said.

Terkmani suffered serious stab wounds to the chest, NSW Police said. 

Aymen Terkmani. (AAP)
Aymen Terkmani during his murder trial in 2017.

It’s believed he was set upon in his cell by two inmates who allegedly stabbed him with a jail-made knife or shiv.

9News understands he may have been targeted after allegedly assaulting another inmate earlier in the day.

It is understood that CCTV has identified several alleged suspects who are now being held in segregation.

He was given medical assistance by prison officers before being airlifted to hospital, however, he was pronounced dead during the flight.

The prison has since been locked down and a crime scene has been established. 

Mahmoud Hrouk, 16, was found bashed to death in Sydney's southwest. (Facebook)
Mahmoud Hrouk, 16, was found bashed to death in Sydney’s south-west. (Facebook) (Facebook)

Terkmani was sentenced in November 2017 to at least 33 years in jail for violently killing 16-year-old Mahmoud Hrouk.

He lured Mahmoud to a vacant house in Fairfield East in Sydney’s south-west, before sexually assaulting and bashing him to death on May 16, 2015.

Mahmoud’s body was found the next day in an abandoned home nearby.

NSW Corrective Services and NSW Police have launched an investigation into Terkmani’s death.

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