As reported by The Blast, Christine McVie was diagnosed with “metastatic malignancy of unknown primary origin” prior to her death. The aggressive form of cancer had spread through her body and doctors were unable to pinpoint the original source. The cancer caused McVie to have an “ischaemic stroke,” which was the primary cause of her death, as well as a bilateral renal infarction. According to The Blast, an ischaemic stroke is “a blood clot [that] blocks or narrows an artery leading to the brain. A blood clot often forms in arteries damaged by the buildup of plaques (atherosclerosis).”
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In June 2022, McVie revealed to Rolling Stone that she was suffering from health issues and was uncertain if she was up to a Fleetwood Mac reunion. “I don’t feel physically up for it,” she says. “I’m in quite bad health. I’ve got a chronic back problem which debilitates me. I stand up to play the piano, so I don’t know if I could actually physically do it. What’s that saying? The mind is willing, but the flesh is weak,” she shared.