The two occupants of a car that exploded at the US-Canada Rainbow Bridge border crossing are dead, a law enforcement source told CNN.

The incident occurred shortly at 11.51am on Wednesday (US time) when a car coming from the Canadian side of the border on the bridge that connects Canada to New York State went through the initial checkpoint where they examine passports and licences and then was directed to another area for a secondary search, according to multiple law enforcement sources.

As the car was heading towards the secondary search area, an explosion occurred, the sources said.

Authorities do not know what caused the explosion.

The FBI is investigating the explosion on the Rainbow Bridge. (Nine)
A US poice officer directs tourists in Niagara Falls, New ork away from the Rainbow Bridge border crossing. (Derek Gee/The Buffalo News via AP) (AP)

The FBI joint Terrorism Task Force is investigating the blast at the Rainbow Bridge border crossing between the US and Canada, adding that the “situation is very fluid”.

Canada’s Prime Minister Justin Trudeau has said there are four border crossings into the United States and Canada that are now closed while the FBI carries out what is now a major investigation.

The FBI is coordinating with local, state and federal law enforcement in the ongoing investigation, it said on X, formerly known as Twitter.

“As this situation is very fluid, that’s all we can say at this time,” the statement said.

The explosion happened on the eve of the Thanksgiving holiday in the US on Thursday, November 23, when millions of Americans travel for celebrations.

Debris is scattered about inside the customs plaza at the Rainbow Bridge border crossing in Niagara Falls, New York state. (Derek Gee/The Buffalo News via AP) (AP)

The Rainbow Bridge crossing connecting the US and Canada near Niagara Falls has been shut down on both sides due to a crash, according to the Niagara International Transportation Technology Coalition.

A vehicle was trying to enter the US side of the border, according to a spokesperson for the Niagara Falls mayor’s office.

“We don’t really know too much – just that there was a vehicle trying to come into the US and they shut down both sides of the bridge,” Aaron Ferguson, public information officer for the city of Niagara Falls, told CNN.

The bridge was reported closed because of the crash, according to the technology coalition.

Law enforcement personnel block off the entrance to the Rainbow Bridge on Wednesday, November 22, 2023, in Niagara Falls. (Derek Gee/The Buffalo News via AP) (AP)

Camera footage from the coalition shows haze surrounding the bridge.

There are four ports of entry between Canada and the US near Niagara Falls, according to US Customs and Border Protection.

This is a breaking story … more to come.

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