Footage of the army helicopter – which was carrying out supply operations – showed it spiralling out of control on Monday before it crashed to the ground in an urban area.
Colombia’s President Gustavo Petro confirmed the incident on Twitter and said emergency services had been deployed to the crash site.
“A few minutes ago, an Army helicopter crashed in Quibdó while carrying out supply tasks. I have given the order to the authorities to move immediately to the area to deal with the emergency and investigate the causes of what happened,” he tweeted.
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Two pilots and two crew members were inside the helicopter at the time of the crash.
The Colombian military said two were dead and two were missing from the crash, local media reports.
Witnesses of the crash said they saw two personnel jump from the helicopter before it impacted.