In video broadcast by the BBC, a silver hatchback can be seen driving directly at the wrought-iron gates which prevent public access to Downing Street.
Armed officers arrested a man at the scene around 4.20pm on Thursday (1.20am Friday AEST) “on suspicion of criminal damage and dangerous driving”, Metropolitan Police said in a statement.
He has been taken into custody and inquiries are ongoing.
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There are no immediate reports of any injuries.
UK’s Met Police have cordoned off Whitehall – the main road running past Downing St and where other politicians are based – in the aftermath of the incident.
Although, that cordon was reportedly significantly reduced an hour after the crash took place.