Police said a BMW and a Mazda were reported stolen from an address in Coonans Street in Pascoe Vale South about 11.40pm yesterday.
It is alleged that a short time later the BMW crashed into a motorcycle at the intersection of Bell and Victoria streets in Preston about 12.40am.
The two occupants from the BMW allegedly ran from the scene.
Officers performed CPR on the male rider but he could not be saved.
A 16-year-old boy was arrested after a short search of the area.
He is currently assisting police with their inquiries.
Anyone who witnessed the collision or who has dashcam, CCTV or any other information is urged to contact Crime Stoppers on 1800 333 000.
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