More than 117 kilograms of drugs have been seized from a Sydney home.

The search of a “safe house” in Pyrmont uncovered 61kg of cocaine blocks, 29kg of ketamine and 27kg of MDMA pills stored in seven suitcases at 10.10am on Friday.

Police have referred to the property as a drug “safe house”.

The total haul is estimated to be worth $42 million in street value.

Two men aged 24 and 31 have been charged with three counts of supplying a prohibited drug of a large commercial quantity.

All the items seized will go through forensic testing.

Detective Superintendent Peter Faux said police will continue to target illegal drug suppliers.

“Our capabilities working with agencies like the NSW Crime Commission mean we can relentlessly pursue anyone involved in putting drugs on our streets,” he said.

Both men were refused bail and will appear in Parramatta local Court today.

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