A man has died in a single-vehicle crash in the Hawkesbury region north of Sydney on Wednesday evening

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A man has died and two children were seriously injured in a single-vehicle crash in the Hawkesbury region north of Sydney on Wednesday evening.

The 40-year-old driver died at the scene and the boys aged 10 and 13 were injured when the car left the road and hit a tree at around 6.45pm.

‘The driver … is yet to be formally identified, but is believed to be a 40-year-old man,’ NSW police said.

A rescue helicopter and two medical crews attended the incident.  

The two boys were treated at the scene on Oakville Road, Oakville by NSW Ambulance paramedics and then taken to Westmead Children’s Hospital in a serious but stable condition.

A man has died in a single-vehicle crash in the Hawkesbury region north of Sydney on Wednesday evening

A man has died in a single-vehicle crash in the Hawkesbury region north of Sydney on Wednesday evening

A man has died in a single-vehicle crash in the Hawkesbury region north of Sydney on Wednesday evening

Two children were also seriously injured in the crash at Oakville Road, Oakville

Two children were also seriously injured in the crash at Oakville Road, Oakville

Two children were also seriously injured in the crash at Oakville Road, Oakville

The older boy is understood to have chest and back pain, while the younger child suffered wrist and lower limb injuries.

The area will be forensically examined in an ongoing investigation, and anyone with dashcam footage or information is urged to contact Crime Stoppers.

A report will be prepared for the coroner.

First responders are pictured at the scene of Wednesday night's car crash tragedy

First responders are pictured at the scene of Wednesday night's car crash tragedy

First responders are pictured at the scene of Wednesday night’s car crash tragedy

The two boys were treated at the scene with the older boy understood to have chest and back pain, while the younger child suffered wrist and lower limb injuries

The two boys were treated at the scene with the older boy understood to have chest and back pain, while the younger child suffered wrist and lower limb injuries

The two boys were treated at the scene with the older boy understood to have chest and back pain, while the younger child suffered wrist and lower limb injuries

The boys were taken to Westmead Children's Hospital in a serious but stable condition

The boys were taken to Westmead Children's Hospital in a serious but stable condition

The boys were taken to Westmead Children’s Hospital in a serious but stable condition

A report on the crash is being prepared for the NSW coroner

A report on the crash is being prepared for the NSW coroner

A report on the crash is being prepared for the NSW coroner

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