Two people, including a 12-year-old girl, are dead after a crash in Sydney’s south-west overnight.

At about 7.40pm, emergency services were called to Milperra Road in Milperra.

They found a Toyota sedan and a Toyota ute had crashed, with the sedan rolling and trapping the driver and passengers.

A 12-year-old girl and a man in his 40s have died after a collision in Milperra, Sydney. (9News)

Two people in the sedan’s back seat, a 41-year-old man and a 12-year-old girl, died at the scene.

A third back-seat passenger, a 10-year-old boy, was taken to hospital in a stable condition.

The driver, a 52-year-old man, was also taken to hospital for mandatory testing.

Three others were taken to hospital. (9News)

The ute driver, a 19-year-old man, was taken to hospital for testing as well.

The road has since been re-opened.

Anybody with information or footage is urged to contact Bankstown police or Crime Stoppers on 1800 333 000.

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